ERRATUM p120 catenin is required for normal renal tubulogenesis and glomerulogenesis

Fig. 8 was not corrected before publication. The correct figure appears below. We apologise to the authors and readers for this mistake. 2099 RESEARCH ARTICLE INTRODUCTION Kidney development serves as a model for examining the mechanisms that underlie organogenesis, including cellular aggregation, polarization, differentiation and mesenchymal-epithelial interactions. Key processes in kidney development are the formation of tubules and the regulation of their luminal diameters. Abnormal regulation of luminal diameter during development or repair leads to cystic kidney disease (Harris, 2009). The kidney comprises nephrons and a collecting system, which are derived from the metanephric mesenchyme and ureteric bud, respectively (Dressler, 2009). During development, inductive signals from the mesenchyme cause the ureteric bud to undergo branching, whereas signals from the ureteric bud induce the conversion of mesenchyme to epithelium (Saxen and Sariola, 1987). Mesenchymal conversion occurs via condensation around ureteric bud tips, followed by formation of pre-tubular cell aggregates, which then form polarized epithelial renal vesicles. The renal vesicles elongate into comma-shaped and then s-shaped bodies. Cells in the proximal domain of the s-shaped body differentiate to form the epithelial cells of the renal glomerulus. Cells in the mid-and distal domains differentiate into the tubular portion of the nephron, which is segmented into proximal tubules, loops of Henle and distal tubules.